The beneficial effects of antioxidants combination on cardiac injury induced by tetrachloromethane.

a.sfakia shared this article with you from Inoreader The beneficial effects of antioxidants combination on cardiac injury induced by tetrachloromethane. Via pubmed: "drug chem toxicol"[... The beneficial effects of antioxidants combination on cardiac injury induced by tetrachloromethane. Drug Chem Toxicol. 2020 Oct 15;:1-9 Authors: Alshanwani AR, Faddah LM, Hagar H, Alhusaini AM, Shaheen S, Mohammad RA, Alharbi FMB, AlHarthii A, Badr AM Abstract The purpose of this research was to evaluate the efficacy of carsil (CAR) either alone or in combination with α-tocopherol (α-TOCO) and/or turmeric (TUMR) against tetrachloromethane (TCM)-induced cardiomyocyte injury in rats. Administration of CAR either alone or in combination with α-TOCO and/or TUMR post-TCM injection, significantly mitigated the increases in serum troponin T, creatine kinase-MB (CK-MB) as well as interleukin-6 (IL-6), interferon γ (IFN-γ), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP). They also decline the elevation of caspase-3, vascular endothelial growth factor (VEGF) protein expression as well as DNA damage in cardiac tissues induced by TCM. The biochemical results were confirmed by histopathological investigation. Conclusion: The combination of the three antioxidants showed greater cardioprotective potential, compared to individual drugs. Therefore, this combination may be recommended as a complementary therapy to antagonize cardia c injury induced by different insults. PMID: 33059470 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.