Protein-protein interactions between virus and host are crucial for infection. SARS-CoV-2, the causative agent of COVID-19 pandemic is an RNA virus prone to mutations. Formation of a stable binding interface between the Spike (S) protein Receptor Binding Domain (RBD) of SARS-CoV-2 and Angiotensin-Converting Enzyme 2 (ACE2) of host actuates viral entry. Yet, how this binding interface evolves as virus acquires mutations during pandemic remains elusive. Here, using a high fidelity bioinformatics pipeline,...
Thu Oct 01, 2020 03:00
Abstract In March 2020, the New York City metropolitan area became the epicenter of the United States’ SARS-CoV-2 pandemic and the surge of new cases threatened to overwhelm the area’s hospital systems. This article describes how an anesthesiology department at a large urban academic hospital rapidly adapted and deployed to meet the threat head-on. Topics included are preparatory efforts, development of a team-based staffing model, and a new strategy for resource management. While...
Thu Oct 01, 2020 03:00
Female physicians represent a growing share of the medical workforce and may have better patient outcomes than male physicians, yet numerous studies have shown that they earn 8 to 29% less than their male counterparts. The magnitude of and reasons for this pay gap are still debated. There are clear…
Thu Oct 01, 2020 03:00
The ultimate goal of human papillomavirus (HPV) vaccination is to prevent invasive cervical cancer by preventing infection with major oncogenic types of HPV. As of December 2019, a total of 124 countries and territories had implemented national immunization programs for HPV vaccination. In Sweden,…
Thu Oct 01, 2020 03:00
Inhibitors of programmed death 1 (PD-1) and its ligand PD-L1, either as monotherapy or combined with chemotherapy, with or without bevacizumab, have emerged as a new standard of care for the first-line treatment of patients with advanced non–small-cell lung cancer (NSCLC) without mutations of…
Thu Oct 01, 2020 03:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08229
Thu Oct 01, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07763
Thu Oct 01, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07375
Thu Oct 01, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07309
Thu Oct 01, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06727
Thu Oct 01, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c09288
Thu Oct 01, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08512
Thu Oct 01, 2020 07:00
Abstract Acute liver injury (ALI) refers to abnormalities in liver function caused by various causes and accompanied by poor prognosis and high mortality. Common predisposing factors for the disease are viral hepatitis, bacteria, alcohol, and certain hepatotoxic drugs. Inflammatory response and oxidative stress are critical for the pathogenesis of ALI. Pterostilbene (Pte), a natural polyphenol product extracted from blueberries and grapes, has been reported that exerted multiple...
03:00
Abstract High-level production of recombinant human interleukin-24 (IL-24), a multifunctional immunomodulatory cytokine, has been challenging due primarily to its aggregation as inclusion bodies in the bacterial host while persistent poor-expression in the insect/mammalian expression systems. The present study presents a robust, vector-host combination (pE-SUMO-IL24), auto-inducible medium (YNG/M9NG), and a simple purification scheme for soluble, bioactive,...
03:00
BACKGROUND AND PURPOSE:Knowledge about predictors of the outcome of flow-diverter treatment is limited. The aim of this study was to predict the angiographic occlusion status after flow-diverter treatment with computational fluid dynamics using porous media modeling for decision-making in the treatment of large wide-neck aneurysms.MATERIALS AND METHODS:A total of 27 patients treated with flow-diverter stents were retrospectively analyzed through computational fluid dynamics using pretreatment patient-specific...
Thu Oct 01, 2020 17:11
SUMMARY:"Asleep" deep brain stimulation using general anesthesia and intraoperative MR imaging guidance is considered "off-label" use by current FDA guidelines but is widely used in neurosurgical practice, and excellent safety has been demonstrated using first-generation, omnidirectional electrodes. Safety data for second-generation, directional electrodes in the interventional MR imaging environment have not yet been published. Herein, we report 34 cases of asleep deep brain stimulation using second-generation,...
Thu Oct 01, 2020 17:14
BACKGROUND AND PURPOSE:Infarct core volume measurement using CTP (CT perfusion) is a mainstay paradigm for stroke treatment decision-making. Yet, there are several downfalls with cine CTP technology that can be overcome by adopting the simple perfusion reconstruction algorithm (SPIRAL) derived from multiphase CTA. We compare SPIRAL with CTP parameters for the prediction of 24-hour infarction.MATERIALS AND METHODS:Seventy-two patients had admission NCCT, multiphase CTA, CTP, and 24-hour DWI. All patients...
Thu Oct 01, 2020 17:16
BACKGROUND AND PURPOSE:Treatment of dural arteriovenous fistulas can be performed by transarterial or transvenous accesses. For those fistulas located at a dural sinus wall, obliteration of the sinus might lead to a substantial risk of complications if the occluded sinus impairs normal venous drainage. For those fistulas with direct leptomeningeal venous drainage, navigation to reach the arteriovenous shunting point of a leptomeningeal vein is usually technically demanding. We report the outcomes...
Thu Oct 01, 2020 17:21
BACKGROUND AND PURPOSE:Detailed arterial anatomy of the sphenoid ridge and olfactory groove meningiomas is complicated due to the fine angioarchitecture and anastomoses between each feeder. Herein, we present details of the arterial anatomy and the relationships of feeders in these lesions.MATERIALS AND METHODS:This study included 20 patients admitted to our department between April 2015 and March 2020. Conditions of subjects consisted of 16 sphenoid ridge meningiomas and 4 olfactory groove meningiomas....
Thu Oct 01, 2020 17:23
Heterozygous familial hypercholesterolemia — in contrast to the more rare and more severe homozygous familial hypercholesterolemia — is a common genetic cholesterol disorder affecting approximately 1 in 250 persons and resulting in an increased risk of premature atherosclerotic cardiovascular…
Thu Oct 01, 2020 03:00
The banana aphid, Pentalonia nigronervosa Coquerel (Hemiptera: Aphididae), is a major pest of cultivated bananas (Musa spp., order Zingiberales), primarily due to its role as a vector of Banana bunchy top virus (BBTV), the most severe viral disease of banana worldwide. Here, we generated a highly complete genome assembly of P. nigronervosa using a single PCR-free Illumina sequencing library. Using the same sequence data, we also generated complete genome assemblies of the P. nigronervosa symbiotic...
00:47
Abstract Rationale Schizophrenia is a devastating mental disease that affects nearly 1% of the population worldwide. It is well documented that the dopaminergic (DAergic) system is compromised in schizophrenia. It is of note that the mixed dopamine (DA) D1/D2 receptor agonist apomorphine induces schizophrenia-like symptoms in rodents, including disruption of memory abilities. Neuroactive steroids, comprising dehydroepiandrosterone (DHEA)...
03:00
Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors’ commentary follows. Stage. A 48-year-old man…
Thu Oct 01, 2020 03:00
The purpose of this work is to create mathematical base and software for solving the problem of finding an evolutionarily stable strategy of zooplankton diel vertical migrations and explaining the observed effects in aquatic ecosystems using this software (in particular, in the northeastern part of the Black Sea). An essential feature of this study is the inclusion in the mathematical model of state constraints on the strategy of behavior, which reflect the vertical limited zone of zooplankton habitat....
Thu Oct 01, 2020 03:00
Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors’ commentary follows. Stage. A 48-year-old man…
Thu Oct 01, 2020 03:00
Background: The nucleotide composition of the genome is a balance between origin and fixation rates of different mutations. For example, it is well-known that transitions occur more frequently than transversions, particularly at CpG sites. Differences in fixation rates of mutation types are less explored. Specifically, recombination-associated GC-biased gene conversion (gBGC) may differentially impact GC-changing mutations, due to differences in their genomic distributions and efficiency of mismatch...
Thu Oct 01, 2020 03:00
Tissue Engineering Part A, Ahead of Print.
Thu Oct 01, 2020 10:00
Tissue Engineering Part A, Ahead of Print.
Thu Oct 01, 2020 10:00
Many bones in the vertebrate skeleton, including the limb bones, axial skeleton, and bones of the floor of the cranium, grow through the process of endochondral ossification, under the control of growth plates. The cellular and molecular mechanisms of endochondral ossification are conserved across these cartilaginous growth plates, increasing the tendency of skeletal elements to covary in size and shape. Covariation at the phenotypic, developmental, and genetic levels has been hypothesized to lead...
Thu Oct 01, 2020 03:00
Abstract Objectives Our primary aim was to validate the Liverpool Peritonsillar abscess Score (LPS) externally in a new patient cohort. Our secondary aim was to modify the LPS in the light of the Covid‐19 pandemic to produce a no‐examination variant for use in this instance. Design Prospective, multicentre external validation study Setting Six different secondary care institutions across the United Kingdom Participants Patients over 16 years old who were referred to ENT with...
Wed Sep 30, 2020 19:30
Abstract Objectives Awake nasopharyngoscopy is routinely performed in the assessment of patients who require treatment for sleep‐disordered breathing (SDB). However, the applicability and accuracy of Müller’s manoeuvre, the main evaluation method for this purpose, are disputable. The current study aimed to introduce an alternative method for awake nasopharyngoscopy in patients with SDB. Design We defined qualitative anatomical features during tidal breathing at the levels of the soft palate,...
Thu Oct 01, 2020 16:14
Abstract Objectives Our primary aim was to validate the Liverpool Peritonsillar abscess Score (LPS) externally in a new patient cohort. Our secondary aim was to modify the LPS in the light of the Covid‐19 pandemic to produce a no‐examination variant for use in this instance. Design Prospective, multicentre external validation study Setting Six different secondary care institutions across the United Kingdom Participants Patients over 16 years old who were referred to ENT with...
Wed Sep 30, 2020 19:30
Abstract Objectives Awake nasopharyngoscopy is routinely performed in the assessment of patients who require treatment for sleep‐disordered breathing (SDB). However, the applicability and accuracy of Müller’s manoeuvre, the main evaluation method for this purpose, are disputable. The current study aimed to introduce an alternative method for awake nasopharyngoscopy in patients with SDB. Design We defined qualitative anatomical features during tidal breathing at the levels of the soft palate,...
Thu Oct 01, 2020 16:14
Abstract Purpose of Review Coding for patient visits and monitoring via telehealth have expanded over the past years with a wide acceptance of telemedicine as a consequence of the coronavirus pandemic. Coding topics of interest to the allergist/immunologist in regard to services provided via telemedicine will be of increasing importance in the coming years. ...
03:00
A 62-year-old man presented to the emergency department with a 2-week history of generalized weakness and a diffuse rash. On examination he had a temperature of 38.1°C (100.6°F). Physical examination showed a maculopapular, hyperpigmented, and scaly eruption on his palms (Panel A), soles (Panel B),…
Thu Oct 01, 2020 03:00
An 83-year-old woman presented to the outpatient clinic with nausea. At the time of presentation, she was receiving antibiotic treatment for cellulitis, and her condition was improving. Her medical history was also notable for an episode of biliary colic when she was 40 years of age. Results of the…
Thu Oct 01, 2020 03:00
Abstract Programmable transcriptional regulation is a powerful tool to study gene functions. Current methods to selectively regulate target genes are mainly based on promoter exchange or on overexpressing transcriptional activators. To expand the discovery toolbox, we designed a dCas9-based RNA-guided synthetic transcription activation system for Aspergillus nidulans that uses enzymatically disabled “dead” Cas9 fused to three consecutive activation domains...
03:00
To the Editor: The standard care for chronic spontaneous urticaria includes second-generation H1-antihistamines, but such treatment is often ineffective, even with four times the dose recommended by the Food and Drug Administration. Urticarial lesions are characterized pathologically by increased…
Thu Oct 01, 2020 03:00
Summary This case report describes our early radiological experiences of middle‐aged patients with COVID‐19 at Westmead Hospital, Sydney. We found limited relationship between initial CT imaging appearances and progression to severe disease. The most effective use of imaging in COVID‐19 is yet to be determined.
Thu Oct 01, 2020 14:57
Abstract Objectives The aim of our study was to describe microbial flora associated with MRONJ and characterize the susceptibility of pathogens to help guide an effective empiric antibiotic treatment in these patients. Materials and methods A retrospective, single-center analysis was performed, using 116 bone samples from 98 patients. The bone samples were...
03:00
Background Patients diagnosed with sarcoma are hypothesized to experience a prolonged route to a cancer diagnosis. This route, the total interval, can be divided into a patient interval (the time from the appearance of symptoms to physician consultation) and diagnostic interval (time from the first consultation to diagnosis). In the current study, the authors investigated these intervals among survivors of sarcoma and identified factors associated with prolonged intervals. Methods A cross‐sectional...
Thu Oct 01, 2020 19:35
Background Surgeons play a pivotal role in combating the opioid crisis that currently grips the United States. Changing surgeon behavior is difficult, and the degree to which behavioral science can steer surgeons toward decreased opioid prescribing is unclear. Methods This was a single‐institution, single‐arm, pre‐ and postintervention study examining the prescribing of opioids by urologists for adult patients undergoing prostatectomy or nephrectomy. The primary outcome was the quantity of...
Thu Oct 01, 2020 19:51
Chronic Respiratory Disease, Volume 17, Issue , January-December 2020. Introduction:The COVID pandemic has had a high psychological impact on healthy populations. Increased levels of perceived stress, depression, and insomnia are expected, especially in people with pre-existing medical conditions, such as asthma and chronic obstructive pulmonary disease (COPD), who seem to be particularly vulnerable. However, the difference in psychological distress frequency between asthma and COPD patients is unknown.Objective:To...
Thu Oct 01, 2020 13:23
Chronic Respiratory Disease, Volume 17, Issue , January-December 2020. The spread of the SARS-CoV-2 infection among population has imposed a re-organization of healthcare services, aiming at stratifying patients and dedicating specific areas where patients with suspected COVID-related respiratory disease could receive the necessary health care assistance while waiting for the confirmation of the diagnosis of COVID-19 disease. In this scenario, the pathway defined as a “grey zone” is strongly advocated....
Thu Oct 01, 2020 13:24
Optical clearing skull window is a novel technique compared to the traditional surgery based cranial window, which could reduce the scattering of skull and make it transparent to visible light. Here, the NIR‐II optimized skull clearing window was established. In the application of NIR‐II excited THG microscopy, the imaging depth was more than 3 times as it without optical clearing, and close to it with the open‐skull window. In addition, the established skull optical clearing window promises to...
10:27
Optical Coherence Tomography angiography (OCTA) is widely used to image chorioretinal vasculature, with contrast that derives from scattering and motion of red blood cells (RBCs). In the rat eye, a scattering tracer highlights vertical vessels which are not visualized by intrinsic RBC scattering alone. The dependence of microvessel OCTA on angular orientation, explored in this work, represents a potential artifact that should be considered in the clinical interpretation of OCTA. Further details...
10:27
Infrared spectroscopy enables insight into light‐activated riboflavin‐induced collagen cross‐linking for future intervertebral disc treatment and repair. Further details can be found in the article by Ioannis Vasilikos, Julian Haas, Graciosa Q. Teixeira, Julia Nothelfer, Cornelia Neidlinger‐Wilke, Hans‐Joachim Wilke, Andreas Seitz, Demetrios G. Vavvas, Josef Zentner, Jürgen Beck, Ulrich Hubbe, and Boris Mizaikoff (e202000110). Abstract Infrared spectroscopy enables insight into light‐activated...
10:27
Biophotonics technologies allow obtaining clinically important diagnostic information about pathological changes that occur in diabetes mellitus, including impaired tissue perfusion and oxygen saturation, structural and functional changes. A review presents the current state‐of‐the‐art in biophotonics technologies and their transfer to clinical use to identify the complications of diabetes mellitus, such as retinopathy, nephropathy, neuropathy, and cardiovascular disease as well as the methods...
10:27
Near‐infrared spectroscopy (NIRS) has been proposed as a noninvasive modality for detecting complications in patients undergoing extracorporeal membrane oxygenation (ECMO), and it can simultaneously reveal the global circulatory status of thesepatients. We monitor the real‐time changes of oxygenation in peripheral tissues to demonstrate the feasibility of NIRS for optimizing ECMO therapy. Further details can be found in the article by Hsiao‐Huang Chang, Yi‐Chih Chen, Chun‐Jung Huang, Chia‐Cheng...
10:27
Low-dose aspirin is recommended by the U.S. Preventive Services Task Force for primary prevention of colorectal cancer in certain individuals. However, broader implementation will require improved precision prevention approaches to identify those most likely to benefit. The major urinary metabolite of PGE2, 11α-hydroxy-9,15-dioxo-2,3,4,5-tetranor-prostane-1,20-dioic acid (PGE-M), is a biomarker for colorectal cancer risk, but it is unknown whether PGE-M is modifiable by aspirin in individuals at...
10:05
Given that high-risk human papillomavirus (HPV) is the necessary cause of virtually all cervical cancer, the clinical meaning of HPV-negative cervical precancer is unknown. We, therefore, conducted a literature search in Ovid MEDLINE, PubMed Central, and Google Scholar to identify English-language studies in which (i) HPV-negative and -positive, histologically confirmed cervical intraepithelial neoplasia grade 2 or more severe diagnoses (CIN2+) were detected and (ii) summarized statistics or deidentified...
10:05
Aspirin and statin use may lower the risk of advanced/fatal prostate cancer, possibly by reducing intraprostatic inflammation. To test this hypothesis, we investigated the association of aspirin and statin use with the presence and extent of intraprostatic inflammation, and the abundance of specific immune cell types, in benign prostate tissue from a subset of men from the placebo arm of the Prostate Cancer Prevention Trial. Men were classified as aspirin or statin users if they reported use at baseline...
10:05
Obesity and obesity-driven cancer rates are continuing to rise worldwide. We hypothesize that adipocyte–colonocyte interactions are a key driver of obesity-associated cancers. To understand the clinical relevance of visceral adipose tissue in advancing tumor growth, we analyzed paired tumor-adjacent visceral adipose, normal mucosa, and colorectal tumor tissues as well as presurgery blood samples from patients with sporadic colorectal cancer. We report that high peroxisome proliferator-activated receptor...
10:05
Obesity is the second leading environmental association with cancer risk; yet, the mechanisms by which obesity drives carcinogenesis are poorly understood. The paper published in this issue of Cancer Prevention Research by Holowatyj and colleagues explores the mechanisms of human visceral adipose–epithelial signaling using samples collected at surgery in patients with invasive colorectal cancer. They identify pathway intermediates potentially involved in the regulation of fibrosis, inflammation,...
10:05
The Women's Health Initiative (WHI) was designed to evaluate the benefits of hormone replacement therapy. The primary goal was to establish the value of synthetic progestin and estrogen or estrogen alone to reduce the risk of coronary heart disease (CHD). The estrogen/synthetic progestin trial was stopped at 5.2 years and the estrogen trial was stopped after 6.8 years. Although the estrogen/synthetic progestin trial was stopped for the anticipated rise in the risk of breast cancer, the estrogen trial...
10:05
Prostate cancer is common in countries with affluent dietary patterns and represents a heterogeneous collection of subtypes with varying behavior. Reductionist strategies focusing on individual nutrients or foods have not clearly defined risk factors. We have developed mechanisms-based dietary patterns focusing upon inflammation and chronic insulin hypersecretion, processes that are hypothesized to impact prostate carcinogenesis. In the Prostate, Lung, Colorectal, and Ovarian cancer cohort, we calculated...
10:05
Although substantial evidence supports aspirin's efficacy in colorectal cancer chemoprevention, key molecular mechanisms are uncertain. An untargeted metabolomics approach with high-resolution mass spectrometry was used to elucidate metabolic effects of aspirin treatment in human colon tissue. We measured 10,269 metabolic features in normal mucosal biopsies collected at colonoscopy after approximately 3 years of randomized treatment with placebo, 81 or 325 mg/day aspirin from 325 participants in...
10:05
Abstract Purpose of the Review Melanin-concentrating hormone (MCH)–expressing neurons located in the lateral hypothalamus are considered as an integral component of sleep-wake circuitry. However, the precise role of MCH neurons in sleep-wake regulation has remained unclear, despite several years of research employing a wide range of techniques. We review recent data on this aspect, which are mostly inconsistent, and propose a...
03:00
Abstract Background To examine the relationship between chronic external and internal head and neck lymphedema (HNL) and swallowing function in patients following head and neck cancer (HNC) treatment. Methods Seventy‐nine participants, 1‐3 years post treatment were assessed for external HNL using the MD Anderson Cancer Centre Lymphedema Rating Scale, and internal HNL using Patterson's Radiotherapy Edema Rating Scale. Swallowing was assessed via instrumental, clinical and patient‐reported...
Thu Oct 01, 2020 11:02
Abstract Background Major milestones of head and neck carcinogenesis have been associated with various genetic abnormalities; however, a clear picture of the molecular networks deregulated during the carcinogenesis of head and neck squamous cell carcinoma (HNSC) has not yet completely revealed. Methods In this study, we used in silico tools and online data sets to evaluate the underlying reasons for the expressional changes of genes residing within the chromosome 3q and to help understanding...
Thu Oct 01, 2020 20:52
Abstract Background Transoral endoscopic vestibular approach (TOEVA) for thyroidectomy (TOETVA) and parathyroidectomy (TOEPVA) is gaining popularity, yet knowledge is based on a limited number of studies, mostly performed by surgeons experienced in laparoscopic\robotic surgery. Methods All patients who underwent TOEVA at our institution between February 2018 and October 2019 were followed prospectively. Main outcomes were ability to accomplish surgery endoscopically (failure defined as...
Thu Oct 01, 2020 21:00
Extent of salvage neck dissection following chemoradiation for locally advanced head and neck cancer
Abstract Background Salvage neck dissection (ND) is the only treatment modality for persistent or recurrent nodal disease after chemoradiotherapy (CRT) for locally advanced head and neck cancer. However, the optimal extent of ND at salvage surgery after definitive CRT is controversial. Methods Our salvage ND procedure is targeted extirpation of nodal disease with resection of only involved areas of nonlymphatic structures. A retrospective analysis of the data indicated a total of 28 targeted...
Thu Oct 01, 2020 21:10
Abstract The food enzyme α‐cyclodextrin glucanotransferase ((1→4)‐α‐d‐glucan 4‐α‐d‐[(1→4)‐α‐d‐glucano]‐transferase; EC 2.4.1.19) is produced with a genetically modified Escherichia coli strain WCM105xpCM703 by Wacker Chemie GmbH. The production strain harbours a self‐replicating multicopy plasmid which contains genes conferring resistance to two highly important antimicrobials for human and veterinary medicine. The food enzyme is free from viable cells of the production organism, but not of its...
Thu Oct 01, 2020 12:26
Abstract The food enzyme β‐cyclodextrin glucanotransferase ((1→4)‐α‐d‐glucan 4‐α‐d‐[(1→4)‐α‐d‐glucano]‐transferase; EC 2.4.1.19) is produced with a genetically modified Escherichia coli strain WCM105xpCM6420 by Wacker Chemie GmbH. The production strain harbours a self‐replicating multicopy plasmid which contains genes conferring resistance to two highly important antimicrobials for human and veterinary medicine. The food enzyme is free from viable cells of the production organism, but not of its...
Thu Oct 01, 2020 12:27
Abstract The food enzyme isoamylase (glycogen α‐1,6‐glucanohydrolase, EC 3.2.1.68) is produced with Dyella sp. by Hayashibara Co. Ltd. Whole genome sequence analysis of the production strain identified a sequence with high homology with a gene conferring resistance to an antimicrobial, which may confer cross‐resistance to a critically important antimicrobial, as defined by the World Health Organisation. This is a concern, since DNA from the production strain was detected in the food enzyme. The...
Thu Oct 01, 2020 12:27
Abstract ObjectiveThe current study aimed to explore the mediating role of body image (dissatisfaction) between sexual functioning and marital intimacy in Pakistani women with breast cancer.Design/ParticipantsCorrelation Research Design was used. 118 women suffering from breast cancer with age (M = 39.58, SD = 11.06) were taken from both Government and Private Hospitals of Lahore, Pakistan. The participants were asked to fill out a set of questionnaires including a Demographic Form, Female Sexual...
Thu Oct 01, 2020 11:30
Abstract ObjectiveUpon receiving a cancer diagnosis, life irrevocably changes and complex experiences of emotional distress often occur. There is a growing interest in mindfulness‐based arts interventions (MBAIs) to ameliorate the distress many patients experience. Our review objective was to synthesize the evidence on the effectiveness of MBAIs on psychological wellbeing and fatigue.MethodRelevant quantitative articles were identified through a systematic search of the grey literature and online...
Thu Oct 01, 2020 12:20
Abstract ObjectiveTamoxifen has been demonstrated to reduce breast cancer risk in high‐risk, premenopausal women. Yet, very few young women with hereditary breast and ovarian cancer syndrome in Australia use tamoxifen despite this being a less invasive option compared to risk‐reducing mastectomy. This study aims to examine young women's decision‐making about and experience of taking tamoxifen to reduce their breast cancer risk.MethodsYoung women with a BRCA1/2 mutation participated in semi‐structured...
Thu Oct 01, 2020 16:44
Abstract ObjectiveGeneric psychosocial screening tools may not reflect the unique symptom profile of brain tumor patients (BTPs). The aim was to adapt the problem list of the Distress Thermometer (DT) for BTPs.MethodsFirst, items of low relevance for BTPs were identified on basis of retrospective analyses. Second, relevant yet missing problems were identified via an extensive literature search, qualitative interviews with BTPs and experts, as well as an online expert survey. The resulting raw version...
Thu Oct 01, 2020 22:13
A new app called the Brink Election Guide will, for the first time ever, make it easier for voters with disabilities to get the information they need to exercise their rights to vote, helping to increase turnout among the 61 million adults with disabilities in America. As COVID-19 pushes everyone online, there is a growing problem of digital accessibility that is negatively impacting voters with disabilities - making it particularly challenging for these users to get information they need on the...
Thu Oct 01, 2020 18:39
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου