Dietary fiber, genetic variations of gut microbiota-derived short-chain fatty acids, and bone health in UK biobank.

a.sfakia shared this article with you from Inoreader Dietary fiber, genetic variations of gut microbiota-derived short-chain fatty acids, and bone health in UK biobank. Via American Goiter Association Dietary fiber, genetic variations of gut microbiota-derived short-chain fatty acids, and bone health in UK biobank. J Clin Endocrinol Metab. 2020 Oct 14;: Authors: Zhou T, Wang M, Ma H, Li X, Heianza Y, Qi L Abstract CONTEXT: Dietary fiber intake may relate to bone health. OBJECTIVE: To investigate whether dietary fiber intake is associated with bone mineral density (BMD), and the modification effect of genetic variations related to gut microbiota-derived short-chain fatty acids (SCFAs). DESIGN: The associations of dietary fiber intake with estimated BMD derived from heel ultrasound and fractures were assessed in 224,630 and 384,134 participants from UK Biobank. SETTING: UK Biobank. MAIN OUTCOME MEASURES: Estimated BMD derived from heel ultrasound. RESULTS: Higher dietary fiber intake (per standard deviation) was significantly associated with higher heel-BMD (β [SE]=0.0047 [0.0003], P=1.10E-54). Similarly significant associations were observed for all the fiber subtypes including cereal, fruit (dried and raw), and vegetable (cooked and raw). (all P<0.05). The positive association was found in both women and men but more marked among men except for dietary fiber in cooked vegetables (All Pinteraction<0.05). A protective association was found between dietary fiber intake and hip fracture (HR, 95% CI: 0.94, 0.89-0.99; P=3.0E-02). In addition, the association between dietary fiber and heel-BMD was modified by genetically determined SCFA propionate production (Pinteraction=5.1E-03). The protective association between dietary fiber and heel-BMD was more pronounced among participants with lower genetically determined propionate production. CONCLUSIONS: Our results indicate that greater intakes of total dietary fiber and subtypes from various food sources are associated with higher heel-BMD. Participants with lower genetically determined propionate production may benefit more from taking more dietary fiber. PMID: 33051670 [PubMed - as supplied by publisher] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.