We found that a single nucleotide polymorphism (SNP) in the nucleoprotein gene of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a patient interfered with detection in a widely used commercial assay. Some 0.2% of the isolates in the EpiCoV database contain this SNP. Although SARS-CoV-2 was still detected by the other probe in the assay, this underlines the necessity of targeting two independent essential regions of a pathogen for reliable detection.
Thu Oct 01, 2020 03:00
Background Respiratory syncytial virus (RSV) is a common cause of severe respiratory illness in young children (< 5 years old) and older adults (≥ 65 years old) leading the World Health Organization (WHO) to recommend the implementation of a dedicated surveillance in countries. Aim We tested the capacity of the severe acute respiratory infection (SARI) hospital network to contribute to RSV surveillance in Belgium. Methods During the 2018/19 influenza season, we started...
Thu Oct 01, 2020 03:00
We report dengue virus (DENV) infection in two Dutch tourists who visited Département Var, southern France, in July and August 2020. As some autochthonous dengue cases have occurred in Europe in recent years, awareness among physicians and public health experts about possible intermittent presence of DENV in southern Europe is important to minimise delay in diagnosis and treatment. Quick diagnosis can lead to timely action to contain the spread of vector-borne diseases and minimise transmission.
Thu Oct 01, 2020 03:00
Background Timely reporting of microbiology test results is essential for infection management. Automated, machine-to-machine (M2M) reporting of diagnostic and antimicrobial resistance (AMR) data from laboratory information management systems (LIMS) to public health agencies improves timeliness and completeness of communicable disease surveillance. Aim We surveyed microbiology data reporting practices for national surveillance of EU-notifiable diseases in European Union/European Economic...
Thu Oct 01, 2020 03:00
During infection by a flavivirus (FV), cells accumulate noncoding subgenomic flavivirus RNAs (sfRNAs) that interfere with several antiviral pathways. These sfRNAs are formed by structured RNA elements in the 3' untranslated region (UTR) of the viral genomic RNA, which block the progression of host cell exoribonucleases that have targeted the viral RNA. Previous work on these exoribonuclease-resistant RNAs (xrRNAs) from mosquito-borne FVs revealed a specific 3-dimensional fold with a unique topology...
Thu Oct 01, 2020 20:16
IL-12 is a very potent cancer immunotherapy agent but is difficult to harness safely if given systemically. Local gene-transfer aims to confine the effects of IL-12 to malignant tissues, thus avoiding toxicity. Lipid-nanoparticled messenger RNA achieves IL-12 expression and efficacy in mouse models, opening the way to an ongoing trial.
Thu Oct 01, 2020 16:46
This article aims to evaluate the diagnostic value of 68Gallium-PSMA positron emission tomography/computerized tomography (68Ga-PSMA PET/CT) for lymph node (LN) staging in patients with prostate cancer (PCa) by a...
Thu Oct 01, 2020 03:00
Abstract Objective Postoperative radiotherapy (RT) is an established treatment for prostate cancer (PC). Though hypofractionation is commonly used for radical treatments, open issues still remain in the postoperative setting due to the lack of long-term data. Aim of this study was to evaluate long-term results of postoperative moderately hypofractionated RT (MHRT). Methods...
Thu Oct 01, 2020 03:00
Objective: The objective of this study was to evaluate the impact of the anterior/posterior status of positive surgical margin (PSM) on long-term outcomes after radical prostatectomy for prostate cancer. Patients and Methods: We included 391 consecutive PSM patients after radical prostatectomy between 1993 and 2007 excluding cases with multiple location PSM or lack of anterior/posterior status data. The oncologic impact of anterior-PSM and posterior-PSM were examined by Kaplan-Meier...
Tue Sep 29, 2020 03:00
Publication date: Available online 30 September 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Dana Connors, Jeff Allen, J.D. Alvarez, Jennifer Boyle, Massimo Cristofanilli, Carolyn Hiller, Susan Keating, Gary Kelloff, Lauren Leiman, Robert McCormack, Diana Merino, Emily Morgan, Klaus Pantel, Christian Rolfo, Maria Jose Serrano, A. Pia Sanzone, Thomas Schlange, Caroline Sigman, Mark Stewart
Thu Oct 01, 2020 21:28
Due to its highly complex nature, in vivo verification of radiotherapy treatment has become increasingly important. An efficient method for performing treatment verification is electronic portal imaging device (EPID) dosimetry. The EPID records exit radiation behind the patient during treatment as 2D images, which are converted to 2D (at the level of the EPID), 3D or 4D doses (in the patient)[1–3]. Measured EPID doses are compared to predicted or planned doses using gamma analysis[4,5], the standard...
Thu Oct 01, 2020 03:00
Mature results from randomised trials of external beam radiotherapy (EBRT) show that biochemical control of disease improves with increasing radiation dose [1–4]. High-dose-rate afterloading brachytherapy (HDR-BT) can deliver a high, localised radiation dose to the prostate with excellent biochemical control of disease and has advantages over external beam radiotherapy (EBRT) because of its ability to overcome problems of organ movement, which confound the external beam techniques used [5–7]despite...
Thu Oct 01, 2020 03:00
Abstract Purpose We report results of a multicenter prospective single-arm phase II trial (ARO-2013-04, NCT01948726) of moderately accelerated hypofractionated radiotherapy with a simultaneous integrated boost (SIB) in patients with breast cancer receiving adjuvant radiotherapy after breast-conserving surgery. Methods The eligibility criteria included...
Thu Oct 01, 2020 03:00
Healthcare utilization and total costs of care among patients with advanced metastatic gastric and esophageal cancer. Future Oncol. 2020 Sep 30;: Authors: Abraham P, Wang L, Jiang Z, Gricar J, Tan H, Kelly RJ Abstract Aim: Study first-line (1L) treatment patterns and economic outcomes among patients with advanced metastatic gastric cancer (GC) and esophageal cancer (EC). Materials & methods: Newly diagnosed patients with systemic GC and...
Thu Oct 01, 2020 19:23
Development of a prognostic model based on an immunogenomic landscape analysis of colorectal cancer.
Development of a prognostic model based on an immunogenomic landscape analysis of colorectal cancer. Future Oncol. 2020 Sep 30;: Authors: Li HJ, Wang YL, Ming L, Guo XQ, Li YL, Wang JC, Zhang YQ, Cheng L Abstract Screening and therapeutic programs for colorectal cancer (CRC) are invasive or not effective and unable to meet patient needs. Major advances in immunogenomics may change this status but need more exploration. Differentially expressed...
Thu Oct 01, 2020 19:23
Publication date: Available online 1 October 2020Source: European Journal of Surgical OncologyAuthor(s): Gianluca Franceschini, Riccardo Masetti
Thu Oct 01, 2020 18:45
Publication date: Available online 1 October 2020Source: European Journal of Surgical OncologyAuthor(s): Shaun Selvadurai, Kulbir Mann, Sanjena Mithra, John Bridgewater, Hassan Malik, Shahid A. Khan
Thu Oct 01, 2020 18:45
Publication date: Available online 1 October 2020Source: European Journal of Surgical OncologyAuthor(s): Peter Schullian, Edward W. Johnston, Daniel Putzer, Gregor Laimer, Gregor Waroschitz, Eva Braunwarth, Arno Amann, Manuel Maglione, Reto Bale
Thu Oct 01, 2020 18:45
Publication date: Available online 30 September 2020Source: European Journal of Surgical OncologyAuthor(s): Jenna L. Morgan, Geoff Holmes, Sue Ward, Charlene Martin, Maria Burton, Stephen J. Walters, Kwok Leung Cheung, Riccardo A. Audisio, Malcolm WR. Reed, Lynda Wyld, Kate Lifford, Adrian Edwards, Kate Brain, Alistair Ring, Thomson Robinson, Tim Chater, Kirsty Pemberton, Anne Shrestha, Anthony Nettleship, Paul Richards
Thu Oct 01, 2020 18:45
Publication date: December 2020Source: Cancer Epidemiology, Volume 69Author(s): Hua Zhao, Jie Shen, Yuanqing Ye, Xifeng Wu, Francisco J. Esteva, Debasish Tripathy, Wong-Ho Chow
Thu Oct 01, 2020 17:28
Abstract Dipeptidyl peptidase-IV (DPP-IV) inhibitors are used to control blood glucose levels in patients with type 2 diabetes. However, the influence of DPP-IV inhibitors on malignant tumors remains unknown. The present study aimed to investigate the effect of the DPP-IV inhibitor saxagliptin on thyroid carcinoma cells. Transwell assays and a nude mouse lung metastasis model were used to evaluate the invasion and metastasis of thyroid carcinoma cells. Western blotting was used...
Thu Oct 01, 2020 03:00
The survival rate is poor in breast cancer patients with brain metastases. Thus, new concepts for therapeutic approaches are required. During metastasis, the cytoskeleton of cancer cells is highly dynamic and ...
Wed Sep 30, 2020 03:00
Publication date: Available online 1 October 2020Source: Practical Radiation OncologyAuthor(s): Yolanda D. Tseng, Kilian E. Salerno, Tracy A. Balboni, American Society for Radiation Oncology’s Guideline Subcommittee
Thu Oct 01, 2020 14:22
Abstract In HPV cervical cancer screening, cytology is used as triage to counter the low specificity of HPV testing. VALID‐SCREEN is a EU‐multicentre, retrospective study conducted to evaluate the clinical performance of the FAM19A4/miR124‐2 methylation‐based molecular triage test as a substitute or addition to cytology as reflex testing of HPV screen positive women. FAM19A4/miR124‐2 methylation test (QIAsure™ Methylation Test) was evaluated in 2384 HPV‐positive cervical screening samples, from...
Wed Sep 30, 2020 22:28
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