Amoxicillin Course Length or Use in Childhood Pneumonia in Underserved Areas

Amoxicillin Course Length or Use in Childhood Pneumonia in Underserved Areas: New England Journal of Medicine, Volume 383, Issue 14, Page 1391-1393, October 2020.

To the Editor: The trials by Ginsberg et al.1 and Jehan et al.2 (July 2 issue) question the recommended treatment of nonsevere pneumonia in children younger than 5 years of age. The trial conducted by Ginsburg et al. in Malawi showed that a 3-day course of amoxicillin was noninferior to a 5-day course, despite the former regimen having been shown to be insufficient in patients with radiologically confirmed pneumonia in a previous trial in Israel.3 The other trial, conducted by Jehan et al. in Pakistan (Randomized Trial of Amoxicillin Versus Placebo for [Fast Breathing] Pneumonia [RETAPP]), did not show noninferiority . . .