Association of MBL2 gene polymorphisms with sepsis in children and adult

Association of MBL2 gene polymorphisms with sepsis in children and adult: Jun-Yi Yao, Zhi-Qian Luo, Wei Zhang, Ying-Qing Li, Yong-Yan Li, Xiu-Ru Li, Wei-Cheng Wang, Zhi-Tao Liu, Shao-Wen Cheng, Chuan-Zhu Lyu



Journal of Acute Disease 2019 8(1):7-11



Sepsis is a syndrome characterized by systemic inflammatory response caused by infection or toxin, with high morbidity and mortality. Different infection microflora and environment have great influence on the occurrence, development and prognosis of sepsis, but individual genetic factors also play an extremely important role. It was reported that the polymorphisms of mannose-binding lectin 2 gene were closely relevant to the occurrence and development of sepsis, but the conclusions in different studies were inconsistent. Therefore, we performed this reviews on the relevance of mannose-binding lectin 2 gene polymorphisms and sepsis.