The expression and function of immunoglobulin-like transcript 4 in dendritic cells from patients with hepatocellular carcinoma.

o.lakala70 shared this article with you from Inoreader The expression and function of immunoglobulin-like transcript 4 in dendritic cells from patients with hepatocellular carcinoma. Via MedWorm Cancer & Oncology Research Authors: Fan J, Han J, Li J, Gu A, Yin D, Song F, Wang L, Yi Y Abstract Due to their easy availability and expansion in vitro, monocyte-derived dendritic cells (moDCs) are most frequently used for tumor vaccination. Immunoglobulin-like transcript 4 (ILT4), as inhibitory receptor, has been reported to be related to DC tolerance. However, the influence of ILT4 for DC tolerance in hepatocellular carcinoma (HCC) patients has not been illustrated. In this research, we explored the expression of ILT4 on moDCs from HCC patients and its effect on moDC function. We demonstrated that the expression of ILT4 on mature DCs (mDCs) was higher in the peripheral blood from HCC patients than in that from healthy donors. The levels of cytokines IL-1β and IL-6 secreted by mDCs from both HCC patients ... MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.