tag:blogger.com,1999:blog-84080709926854448832024-03-20T08:12:25.397-07:00Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. ΣφακιανάκηςΩτοΡινοΛαρυγγολόγος Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.comBlogger20853125tag:blogger.com,1999:blog-8408070992685444883.post-69521736557579996632023-02-19T21:33:00.001-08:002023-02-19T21:33:08.103-08:00Validation of indications for enucleation for benign parotid gland tumors<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c2c97c16?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://onlinelibrary.wiley.com/doi/10.1002/hed.27321?af=R" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">Validation of indications for enucleation for benign parotid gland tumors</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2F%28ISSN%291097-0347">Head & Neck</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> <h2>Abstract</h2> <h2>Background</h2> <p>Enucleation has been reported as a minimally invasive surgery for Warthin's tumor (WT). However, the definite indications for enucleation have not been clarified.</p> <h2>Methods</h2> <p>Enucleation was indicated by the following findings: findings of WT, cystic fluid, or benign leukocytes by fine-needle aspiration cytology; a well-margined and homogeneous pattern on imaging; and a tumor location in the tail or preauricular area of the parotid gland. We reviewed 552 cases treated with parotid gland surgery in our hospital.</p> <h2>Results</h2> <p>A total of 108 tumors were treated with enucleation and included no malignant solid tumors or pleomorphic adenoma. Enucleation demonstrated low invasiveness and complication rates. Revision surgery for WT reappearance after enucleation was rare and showed minimal scarring, with a lower risk of facial weakness.</p> <h2>Conclusions</h2> <p>The indication criteria for enucleation were validated. Such enucleation is useful, as it is associated with minimal invasiveness, low complication rates, and safety in revision surgery.</p> <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://onlinelibrary.wiley.com/doi/10.1002/hed.27321?af=R" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com1tag:blogger.com,1999:blog-8408070992685444883.post-61646068920985704522023-02-19T21:29:00.001-08:002023-02-19T21:29:36.340-08:00Multifunctional Two-Dimensional Bi2Se3 Nanodiscs for Anti-Inflammatory Therapy of Inflammatory Bowel Diseases<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c2430d9b?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://www.sciencedirect.com/science/article/pii/S1742706123000855?dgcid=rss_sd_all" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">Multifunctional Two-Dimensional Bi<sub>2</sub>Se<sub>3</sub> Nanodiscs for Anti-Inflammatory Therapy of Inflammatory Bowel Diseases</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://www.sciencedirect.com/">ScienceDirect Publication Acta Biomaterialia</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> <p class="p_no_top"><div class="pin_container" style="float:none"><div id="pc_723545" class="pin_chiclet pc_first" title="Pin this image to Pinterest. Right-click to turn-off this feature."><span class="icon-service_pinterest-16x16"></span></div><img src="https://www.inoreader.com/camo/sxYk-glr9b_dvcMmTgVbypYel22wvT3zwE372-nUx1bg,b64/aHR0cHM6Ly9hcnMuZWxzLWNkbi5jb20vY29udGVudC9pbWFnZS8xLXMyLjAtUzE3NDI3MDYxMjMwMDA4NTUtZ2ExLmpwZw" alt="1-s2.0-S1742706123000855-ga1.jpg" data-original-src="https://ars.els-cdn.com/content/image/1-s2.0-S1742706123000855-ga1.jpg" style="max-width: 650px; height: auto; object-fit: contain;" class="article_block_image"></div><br></p> <p>Publication date: Available online 17 February 2023</p> <p><b>Source:</b> Acta Biomaterialia</p> <p>Author(s): Cong Zhang, Qingrong Li, Jie Shan, Jianghao Xing, Xiaoyan Liu, Yan Ma, Haisheng Qian, Xulin Chen, Xianwen Wang, Lian-Ming Wu, Yue Yu</p> <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://www.sciencedirect.com/science/article/pii/S1742706123000855?dgcid=rss_sd_all" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-29767034297372018072023-02-19T21:27:00.001-08:002023-02-19T21:29:31.291-08:00An integrated strategy to identify COVID‐19 causal genes and characteristics represented by LRRC37A2<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c2018cd0?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://onlinelibrary.wiley.com/doi/10.1002/jmv.28585?af=R" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">An integrated strategy to identify COVID‐19 causal genes and characteristics represented by LRRC37A2</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2F%28ISSN%291096-9071">Journal of Medical Virology</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> <h2>ABSTRACT</h2> <p>Genome-wide association study (GWAS) could identify host genetic factors associated with coronavirus disease 2019 (COVID-19). The genes or functional DNA elements through which genetic factors affect COVID-19 remain uncharted. The expression quantitative trait locus (eQTL) provides a path to assess the correlation between genetic variations and gene expression. Here, we firstly annotated GWAS data to describe genetic effects, obtaining genome-wide mapped genes. Subsequently, the genetic mechanisms and characteristics of COVID-19 were investigated by an integrated strategy that included three GWAS-eQTL analysis approaches. It was found that 20 genes were significantly associated with immunity and neurological disorders, including prior and novel genes such as OAS3 and LRRC37A2. The findings were then replicated in single-cell datasets to explore the cell-specific expression of causal genes. Furthermore, associations between COVID-19 and neurological disorders were assessed as a cau sal relationship. Finally, the effects of causal protein-coding genes of COVID-19 were discussed using cell experiments. The results revealed some novel COVID-19-related genes to emphasize disease characteristics, offering a broader insight into the genetic architecture underlying the pathophysiology of COVID-19.</p> <p>This article is protected by copyright. All rights reserved.</p> <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://onlinelibrary.wiley.com/doi/10.1002/jmv.28585?af=R" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-29518435670399758972023-02-19T21:27:00.000-08:002023-02-19T21:29:16.189-08:00Downregulation of miR‐193a/b‐3p during HPV‐induced cervical carcinogenesis contributes to anchorage‐independent growth through PI3K/AKT pathway regulators<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c2bf04db?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://onlinelibrary.wiley.com/doi/10.1002/jmv.28589?af=R" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">Downregulation of miR‐193a/b‐3p during HPV‐induced cervical carcinogenesis contributes to anchorage‐independent growth through PI3K/AKT pathway regulators</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2F%28ISSN%291096-9071">Journal of Medical Virology</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> <h2>Abstract</h2> <p>Cervical cancer is caused by a persistent infection with high-risk types of HPV and an accumulation of (epi)genetic alterations in host cell. Acquisition of anchorage-independent growth represents a critical hallmark during HPV-induced carcinogenesis, thereby yielding the most valuable biomarkers for early diagnosis and therapeutic targets. In a previous study, we found that miR-193a-3p and miR-193b-3p were involved in anchorage-independent growth. This study aimed to delineate the role of miR-193a/b-3p in HPV-induced carcinogenesis and to identify their target genes related to anchorage-independent growth. Cell viability and colony formation were assessed in SiHa cancer cells and HPV-16 and -18 immortalized keratinocytes upon miR-193a/b-3p overexpression. Both miRNAs reduced cell growth of all three cell lines in low-attachment conditions and showed a minor effect in adherent conditions. Online target predicting programs and publicly available expression data were used to find ca ndidate mRNAs targets of miR-193a/b-3p. Seven targets showed reduced mRNA expression upon miR-193a/b-3p overexpression. For 3 targets Western blot analysis was also performed, all showing a reduced protein expression. A direct interaction was confirmed using luciferase assays for 6 genes: LAMC1, PTK2, STMN1, KRAS, SOS2, and PPP2R5C, which are PIK3/AKT regulators. All 6 targets were overexpressed in cervical cancers and/or precursor lesions. Together with an oberserved downregulation of phosphorylated-AKT upon miR-193a/b-3p overexpression, this underlines the biological relevance of miR-193a/b-3p downregulation during HPV-induced cervical carcinogenesis.</p> <p>In conclusion, downregulation of miR-193a-3p and miR-193b-3p is functionally involved in the acquisition of HPV-induced anchorage independence by targeting regulators of the PIK3/AKT pathway.</p> <p>This article is protected by copyright. All rights reserved.</p> <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://onlinelibrary.wiley.com/doi/10.1002/jmv.28589?af=R" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-57882159568795747622023-02-19T21:26:00.001-08:002023-02-19T21:26:41.265-08:00Assessment of attenuation of varicella‐zoster virus vaccines based on genomic comparison<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c1343bea?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://onlinelibrary.wiley.com/doi/10.1002/jmv.28590?af=R" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">Assessment of attenuation of varicella‐zoster virus vaccines based on genomic comparison</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2F%28ISSN%291096-9071">Journal of Medical Virology</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> <h2>Abstract</h2> <p>Live attenuated varicella zoster virus (VZV) vaccines are used to prevent chickenpox and shingles. Single nucleotide polymorphisms (SNPs) that occur during the attenuation of parental strains are critical indicators of vaccine safety. To assess the attenuation of commercial VZV vaccines, genetic variants were comprehensively examined through high-throughput sequencing of viral DNA isolated from four VZV vaccines (Barycela, VarilRix, VariVax, and SKY Varicella). Whole-genome comparison of the four vaccines with the wild-type strain (Dumas) revealed that the sequences are highly conserved on a genome-wide scale. Among the 196 common variants across the four vaccines, 195 were already present in the genome of the parental strain (pOka), indicating that the variants occurred during the generation of the parental strain from the Dumas strain. Compared to the pOka genome, the vaccines exhibited distinct variant frequencies on a genome-wide and within an attenuation-related open reading frame (ORF). In particular, attenuation-associated 42 SNPs showed that Barycela, VarilRix, VariVax, and SKY Varicella are in ascending order regarding similarity with pOka-like genotypes, which in turn, might provide genomic evidence for the levels of attenuation. Finally, the phylogenetic network analysis demonstrated that genetic distances from the parental strain correlated with the attenuation levels of the vaccines.</p> <p>This article is protected by copyright. All rights reserved.</p> <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://onlinelibrary.wiley.com/doi/10.1002/jmv.28590?af=R" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-21582112888372948732023-02-19T21:25:00.001-08:002023-02-19T21:25:45.293-08:00Pustular psoriasis in Malaysia: A review of the Malaysian Psoriasis Registry 2007 – 2018<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c206202e?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://onlinelibrary.wiley.com/doi/10.1111/exd.14770?af=R" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">Pustular psoriasis in Malaysia: A review of the Malaysian Psoriasis Registry 2007 – 2018</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="https://onlinelibrary.wiley.com/journal/16000625?af=R">Wiley: Experimental Dermatology: Table of Contents</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> <h2>Abstract</h2> <h2>Background</h2> <p>Pustular psoriasis (PP) is an uncommon subtype of psoriasis with distinct genetic features and clinical phenotypes. Patients with PP tend to experience frequent flares and significant morbidity. This study aims to determine the clinical characteristics, comorbidities and treatment of PP patients in Malaysia.</p> <h2>Methods</h2> <p>This was a cross-sectional study of patients with PP notified to the Malaysian Psoriasis Registry (MPR) between January 2007 to December 2018.</p> <h2>Results</h2> <p>Of 21,735 psoriasis patients, 148 (0.7%) had pustular psoriasis. Of these, 93 (62.8%) were diagnosed with generalized pustular psoriasis (GPP) and 55 (37.2%) with localized PP (LPP). The mean age for pustular psoriasis onset was 31.71 ± 18.33 years with a male to female ratio of 1:2.1. Patients with PP were more likely to have dyslipidemia (23.6% vs 16.5%, <i>p</i>=0.022), severe disease [Body surface area >10 and/or Dermatology Life Quality Index (DLQI) >10] (64.8% vs 50%, <i>p</i>=0.003) and require systemic therapy (51.4% vs 13.9%, <i>p</i><0.001) compared to non-PP patients. Patients with PP also suffered greater impairment to their quality of life (DLQI>10, 48.9% vs 40.3%, <i>p</i>=0.046), had more days off school/work (2.06 ± 6.09 vs 0.5 ± 4.91, <i>p</i>=0.004) and a higher mean number of hospitalizations (0.31 ± 0.95 vs 0.05 ± 1.22, <i>p</i>=0.001) in 6 months compared to non-PP patients.</p> <h2>Conclusion</h2> <p>Overall, 0.7% of psoriasis patients in the MPR had pustular psoriasis. Patients with PP had a higher rate of dyslipidaemia, severe disease, greater impairment of quality of life, and systemic therapy usage compared to other psoriasis subtypes.</p> <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://onlinelibrary.wiley.com/doi/10.1111/exd.14770?af=R" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-26620724069012329962023-02-19T21:22:00.001-08:002023-02-19T21:22:47.776-08:00Impact of Exercise and Detraining on Signs of Puberty and Selected Inflammatory Markers in Girls with Precocious Puberty<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c142bd7d?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://journals.lww.com/acsm-msse/Fulltext/9900/Impact_of_Exercise_and_Detraining_on_Signs_of.215.aspx" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">Impact of Exercise and Detraining on Signs of Puberty and Selected Inflammatory Markers in Girls with Precocious Puberty</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://journals.lww.com/acsm-msse/toc/9000/00000">Medicine & Science in Sports & Exercise - Published Ahead-of-Print</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> <p class="p_no_top"><div class="pin_container" style="float:none"><div id="pc_96071" class="pin_chiclet pc_first" title="Pin this image to Pinterest. Right-click to turn-off this feature."><span class="icon-service_pinterest-16x16"></span></div><img src="https://www.inoreader.com/camo/sLffXmOVAavESnNsLBdYKC-k2rCZ4-zhcX3pie9Sb7pg,b64/aHR0cHM6Ly9pbWFnZXMuam91cm5hbHMubHd3LmNvbS9hY3NtLW1zc2UvU29jaWFsVGh1bWIuMDAwMDU3NjguREMuanBlZw" alt="SocialThumb.00005768.DC.jpeg" data-original-src="https://images.journals.lww.com/acsm-msse/SocialThumb.00005768.DC.jpeg" style="max-width: 650px; height: auto; object-fit: contain; width: 100%;" class="article_block_image"></div><br></p> <a href="https://journals.lww.com/acsm-msse/Fulltext/9900/Impact_of_Exercise_and_Detraining_on_Signs_of.215.aspx" target="_blank" rel="noopener" class="underlink bluelink"></a>Purpose We examined the effects of aerobic exercise and detraining on adiponectin, resistin, tumor necrosis factor alpha (TNF-α), white blood cell, and pubertal signs (uterine length, ovarian volume, luteinizing hormone (LH), and follicle-stimulating hormone (FSH)) in girls with central precocious puberty (CPP). Methods Thirty girls with CPP (aged 7-9) were randomly divided into CPP and CPP + Exercise (EX) groups. 15 Healthy age-matched girls without precocious puberty participated for comparison with CPP. Subjects in the CPP + Ex group attended 12 weeks of aerobic exercise protocol three sessions a week. In the baseline, after completing the exercise protocol and after 4 weeks of detraining, all the parameters were measured. In the CPP and healthy groups, all the parameters were measured in all three stages. To measure adiponectin, resistin, and TNF-α, the ELISA method was used. LH and FSH were measured by electrochemiluminescence immunoassay. WBC counts were analyzed by an automated blood cell counter. Analysis of Variance with repeated measures test was used to analyze the results. Results CPP girls have lower adiponectin (P = 0.01) and higher TNF-α levels (P = 0.001) than healthy girls. In the CPP + EX group, after 12 weeks, body weight and fat mass decreased, adiponectin increased significantly (P = 0.02). Resistin (P = 0.02), TNF-α (P = 0.02), neutrophils (P = 0.01), and signs of puberty significantly (P <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://journals.lww.com/acsm-msse/Fulltext/9900/Impact_of_Exercise_and_Detraining_on_Signs_of.215.aspx" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-11142109481434750952023-02-19T21:21:00.001-08:002023-02-19T21:21:27.948-08:00LRRK2 Quantification in Cerebrospinal Fluid of Patients with Parkinson's Disease and Atypical Parkinsonian Syndromes<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c14614ab?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.29336?af=R" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">LRRK2 Quantification in Cerebrospinal Fluid of Patients with Parkinson's Disease and Atypical Parkinsonian Syndromes</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2F%28ISSN%291531-8257">Movement Disorders</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> <h2>Abstract</h2> <h2>Background</h2> <p>The alteration of leucine-rich repeat kinase 2 (LRRK2) kinase activity is thought to be involved in Parkinson's disease (PD) pathogenesis beyond familiar cases, and LRRK2 inhibitors are currently under investigation. Preliminary data suggest a relationship between LRRK2 alteration and cognitive impairment in PD.</p> <h2>Objective</h2> <p>To investigate cerebrospinal fluid (CSF) LRRK2 levels in PD and other parkinsonian disorders, also correlating them with cognitive impairment.</p> <h2>Methods</h2> <p>In this study, we retrospectively investigated by means of a novel highly sensitive immunoassay the levels of total and phosphorylated (pS1292) LRRK2 in CSF of cognitively unimpaired PD (n = 55), PD with mild cognitive impairment (n = 49), PD with dementia (n = 18), dementia with Lewy bodies (n = 12), atypical parkinsonian syndromes (n = 35), and neurological controls (n = 30).</p> <h2>Results</h2> <p>Total and pS1292 LRRK2 levels were significantly higher in PD with dementia with respect to PD with mild cognitive impairment and PD, and also showed a correlation with cognitive performances.</p> <h2>Conclusions</h2> <p>The tested immunoassay may represent a reliable method for assessing CSF LRRK2 levels. The results appear to confirm an association of LRRK2 alteration with cognitive impairment in PD. © 2023 The Authors. <i>Movement Disorders</i> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</p> <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.29336?af=R" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-10928048305042442382023-02-19T21:18:00.003-08:002023-02-19T21:18:18.876-08:00Central odontogenic fibroma with amyloid: a diagnostically challenging case<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c2eda406?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://medworm.com/1078570403/central-odontogenic-fibroma-with-amyloid-a-diagnostically-challenging-case/" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">Central odontogenic fibroma with amyloid: a diagnostically challenging case</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://www.medworm.com/rss/search.php?qu=International+Journal+of+Oral+and+Maxillofacial+Surgery&t=International+Journal+of+Oral+and+Maxillofacial+Surgery&s=Search&f=source">International Journal of Oral and Maxillofacial Surgery via MedWorm.com</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> Odontogenic fibroma is a rare benign mesenchymal odontogenic tumor, with its histological diversity possibly posing diagnostic challenges. A case of the amyloid variant of central odontogenic fibroma, with epithelial cells in perineural and intraneural locations, is reported herein. The 46-year-old female patient had experienced discomfort related to her anterior right hard palate for approximately 25 years. Clinical examination revealed a depression in the anterior hard palate, and radiographic examination showed a well-defined radiolucent lesion with root resorption of the adjacent teeth. (Source: International Journal of Oral and Maxillofacial Surgery) <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://medworm.com/1078570403/central-odontogenic-fibroma-with-amyloid-a-diagnostically-challenging-case/" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-69956351034921519132023-02-19T21:18:00.001-08:002023-02-19T21:18:10.810-08:00Xenogeneic collagen matrix versus connective tissue graft for soft tissue augmentation at immediately placed implants: a prospective clinical trial<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c18fcaeb?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://medworm.com/1078896023/xenogeneic-collagen-matrix-versus-connective-tissue-graft-for-soft-tissue-augmentation-at-immediatel/" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">Xenogeneic collagen matrix versus connective tissue graft for soft tissue augmentation at immediately placed implants: a prospective clinical trial</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://www.medworm.com/rss/search.php?qu=International+Journal+of+Oral+and+Maxillofacial+Surgery&t=International+Journal+of+Oral+and+Maxillofacial+Surgery&s=Search&f=source">International Journal of Oral and Maxillofacial Surgery via MedWorm.com</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> The advantages of immediate implant placement for patients include a reduced number of surgical procedures and a shorter overall treatment time. Disadvantages include a higher risk of aesthetic complications. The aim of this study was to compare xenogeneic collagen matrix (XCM) versus a subepithelial connective tissue graft (SCTG) used for soft tissue augmentation in combination with immediate implant placement without provisionalization. Forty-eight patients requiring a single implant-supported rehabilitation were selected and assigned to one of two surgical procedures: immediate implant with SCTG (SCTG group) or immediate implant with XCM (XCM group). (Source: International Journal of Oral and Maxillofacial Surgery) <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://medworm.com/1078896023/xenogeneic-collagen-matrix-versus-connective-tissue-graft-for-soft-tissue-augmentation-at-immediatel/" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-90043126669725425502023-02-19T21:17:00.001-08:002023-02-19T21:17:13.848-08:00Tixagevimab/Cilgavimab Treatment and Cardiovascular Events: Immortal time bias<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c224b097?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad089/7043777?rss=1" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">Tixagevimab/Cilgavimab Treatment and Cardiovascular Events: Immortal time bias</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://academic.oup.com/cid">Clinical Infectious Diseases Advance Access</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> <p class="p_no_top"><div class="pin_container" style="float:none"><div id="pc_977590" class="pin_chiclet pc_first" title="Pin this image to Pinterest. Right-click to turn-off this feature."><span class="icon-service_pinterest-16x16"></span></div><img src="https://www.inoreader.com/camo/sFa8VwVIOH2lj8CjzKdesGzw5-iIN_uy85bXMcDjlifs,b64/aHR0cHM6Ly9hY2FkZW1pYy5vdXAuY29tL2RhdGEvc2l0ZWJ1aWxkZXJhc3NldHNvcmlnaW5hbHMvbGl2ZS9pbWFnZXMvY2lkL2NpZF9vZ2ltYWdlLnBuZw" alt="cid_ogimage.png" data-original-src="https://academic.oup.com/data/sitebuilderassetsoriginals/live/images/cid/cid_ogimage.png" style="max-width: 650px; height: auto; object-fit: contain; width: 100%;" class="article_block_image"></div><br></p> <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad089/7043777?rss=1" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-64867417825485221762023-02-19T21:16:00.001-08:002023-02-19T21:16:42.371-08:00Recombinant measles virus encoding the spike protein of SARS-CoV-2 efficiently induces Th1 responses and neutralizing antibodies that block SARS-CoV-2 variants<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c2ff57c7?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://medworm.com/1078658245/recombinant-measles-virus-encoding-the-spike-protein-of-sars-cov-2-efficiently-induces-th1-responses/" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">Recombinant measles virus encoding the spike protein of SARS-CoV-2 efficiently induces Th1 responses and neutralizing antibodies that block SARS-CoV-2 variants</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://www.medworm.com/rss/search.php?qu=Vaccine&t=Vaccine&s=Search&f=source">Vaccine</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> <p class="p_no_top"><img src="https://www.inoreader.com/camo/swuX8vVj3utUyZW5BrwxIyqC8dt-FwoeZEUna4RA5RCc,b64/aHR0cHM6Ly9tZWR3b3JtLmNvbS9pbWFnZXMvZmJ3b3JtLnBuZw" alt="fbworm.png" data-original-src="https://medworm.com/images/fbworm.png" style="max-width: 650px; height: auto; object-fit: contain;"></p>In this study, we developed a recombinant MeV expressing the full-length SARS-CoV-2 spike protein (rMeV-S) and tested its efficacy using mouse and hamster models. In hCD46Tg mice, two-dose rMeV-S vaccination induced higher Th1 secretion and humoral responses than one-dose vaccination. Interestingly, neutralizing antibodies induced by one-dose and two-dose rMeV-S immunization effectively blocked the entry of the α, β, γ, and δ variants of SARS-CoV-2. Furthermore, two-dose rMeV-S immunization provided complete protection against SARS-CoV-2 in the hamster model. These results suggest the potential of rMeV-S as a vaccine candidate for targeting SARS-CoV-2 and its variants.PMID:3679 2434 | DOI:10.1016/j.vaccine.2023.02.005 (Source: Vaccine) <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://medworm.com/1078658245/recombinant-measles-virus-encoding-the-spike-protein-of-sars-cov-2-efficiently-induces-th1-responses/" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-62489749658493642732023-02-19T21:15:00.001-08:002023-02-19T21:15:36.090-08:00Characterization of protein-based risk signature to predict prognosis and evaluate the tumor immune environment in breast cancer<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c1b599be?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://medworm.com/1079091706/characterization-of-protein-based-risk-signature-to-predict-prognosis-and-evaluate-the-tumor-immune-/" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">Characterization of protein-based risk signature to predict prognosis and evaluate the tumor immune environment in breast cancer</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://www.medworm.com/rss/search.php?qu=Breast+Cancer&t=Breast+Cancer&s=Search&f=source">Breast Cancer</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> CONCLUSION: This study established an effective prognostic proteomics signature with reliable predictive performance for survival, immune activity, and drug sensitivity. It might provide a novel perspective into the protein function in BC, and guide the individual treatment strategies for BC patients.PMID:36732487 | DOI:10.1007/s12282-023-01435-8 (Source: Breast Cancer) <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://medworm.com/1079091706/characterization-of-protein-based-risk-signature-to-predict-prognosis-and-evaluate-the-tumor-immune-/" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-58341575541560890212023-02-19T21:14:00.003-08:002023-02-19T21:14:36.322-08:00Diagnostic Confirmation of Choroidal Lymphoma by Anterior Chamber Paracentesis and Aqueous Fluid Flow Cytometry<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c18850c8?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://medworm.com/1069559049/diagnostic-confirmation-of-choroidal-lymphoma-by-anterior-chamber-paracentesis-and-aqueous-fluid-flo/" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">Diagnostic Confirmation of Choroidal Lymphoma by Anterior Chamber Paracentesis and Aqueous Fluid Flow Cytometry</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://www.medworm.com/rss/search.php?qu=Ocular+Immunology+and+Inflammation&t=Ocular+Immunology+and+Inflammation&s=Search&f=source">Ocular Immunology and Inflammation</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> CONCLUSIONS: Definitive diagnosis in suspected cases of choroidal lymphoma remains challenging. Ocular fluid sampling may be a low morbidity and convenient alternative for confirming a suspected diagnosis in cases associated with cellular infiltration of the intraocular fluids.PMID:36637999 | DOI:10.1080/09273948.2022.2162421 (Source: Ocular Immunology and Inflammation) <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://medworm.com/1069559049/diagnostic-confirmation-of-choroidal-lymphoma-by-anterior-chamber-paracentesis-and-aqueous-fluid-flo/" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-56659264320244319052023-02-19T21:14:00.001-08:002023-02-19T21:14:14.207-08:00Acute Posterior Multifocal Placoid Pigment Epitheliopathy: A Rare Presentation of Anklylosing Spondylitis or a Paradoxical Reaction to Secukinumab?<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c18850cd?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://medworm.com/1066978575/acute-posterior-multifocal-placoid-pigment-epitheliopathy-a-rare-presentation-of-anklylosing-spondy/" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">Acute Posterior Multifocal Placoid Pigment Epitheliopathy: A Rare Presentation of Anklylosing Spondylitis or a Paradoxical Reaction to Secukinumab?</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://www.medworm.com/rss/search.php?qu=Ocular+Immunology+and+Inflammation&t=Ocular+Immunology+and+Inflammation&s=Search&f=source">Ocular Immunology and Inflammation</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> CONCLUSION: In AS patients, posterior uveitis can manifest as APMPPE. It should be recorded as an entity to be considered in the differential diagnosis.PMID:36608284 | DOI:10.1080/09273948.2022.2150225 (Source: Ocular Immunology and Inflammation) <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://medworm.com/1066978575/acute-posterior-multifocal-placoid-pigment-epitheliopathy-a-rare-presentation-of-anklylosing-spondy/" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-17614863547222546982023-02-16T22:34:00.001-08:002023-02-16T22:34:22.735-08:00Operation early‐bird: Investigating altered light exposure in military barracks on sleep and performance—a placebo‐controlled study<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c334b221?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://onlinelibrary.wiley.com/doi/10.1111/jsr.13837?af=R" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">Operation early‐bird: Investigating altered light exposure in military barracks on sleep and performance—a placebo‐controlled study</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2F%28ISSN%291365-2869">Journal of Sleep Research</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> <h2>Summary</h2> <p>The manipulation of light exposure in the evening has been shown to modulate sleep, and may be beneficial in a military setting where sleep is reported to be problematic. This study investigated the efficacy of low-temperature lighting on objective sleep measures and physical performance in military trainees. Sixty-four officer-trainees (52 male/12 female, mean ± SD age: 25 ± 5 years) wore wrist-actigraphs for 6 weeks during military training to quantify sleep metrics. Trainee 2.4-km run time and upper-body muscular-endurance were assessed before and after the training course. Participants were randomly assigned to either: low-temperature lighting (LOW, <i>n</i> = 19), standard-temperature lighting with a placebo "sleep-enhancing" device (PLA, <i>n</i> = 17), or standard-temperature lighting (CON, <i>n</i> = 28) groups in their military barracks for the duration of the course. Repeated-measures ANOVAs were run to identify significant differences with post hoc ana lyses and effect size calculations performed where indicated. No significant interaction effect was observed for the sleep metrics; however, there was a significant effect of time for average sleep duration, and <i>small</i> benefits of LOW when compared with CON (<i>d</i> = 0.41–0.44). A significant interaction was observed for the 2.4-km run, with the improvement in LOW (Δ92.3 s) associated with a <i>large</i> improvement when compared with CON (Δ35.9 s; <i>p</i> = 0.003; <i>d</i> = 0.95 ± 0.60), but not PLA (Δ68.6 s). Similarly, curl-up improvement resulted in a <i>moderate</i> effect in favour of LOW (Δ14 repetitions) compared with CON (Δ6; <i>p</i> = 0.063; <i>d</i> = 0.68 ± 0.72). Chronic exposure to low-temperature lighting was associated with benefits to aerobic fitness across a 6-week training period, with minimal effects on sleep measures.</p> <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://onlinelibrary.wiley.com/doi/10.1111/jsr.13837?af=R" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-74899145232888175282023-02-16T22:33:00.001-08:002023-02-16T22:33:29.200-08:00Efficacy of adjunctive measures in peri‐implant mucositis. A systematic review and meta‐analysis<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c348f0be?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://onlinelibrary.wiley.com/doi/10.1111/jcpe.13791?af=R" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">Efficacy of adjunctive measures in peri‐implant mucositis. A systematic review and meta‐analysis</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2F%28ISSN%291600-051X">Journal of Clinical Periodontology</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> <h2>Abstract</h2> <h2>Aim</h2> <p>To answer the following PICO question: <i>In systemically healthy humans with peri-implant mucositis (PiM), what is the efficacy of patient-performed or administered (by prescription) measures used adjunctively to submarginal instrumentation, as compared to submarginal instrumentation alone or combined with a negative control, in terms of reducing bleeding on probing (BOP), in randomized controlled clinical trials (RCTs) with at least 3-month follow-up?</i></p> <h2>Material and methods</h2> <p>Three databases were searched until April 2022. Weighted mean differences (WMD) with 95% confidence intervals (CIs) and predictive intervals were calculated.</p> <h2>Results</h2> <p>16 parallel RCTs corresponding to 14 studies with low/moderate risk of bias were included. Test groups showed greater reductions in BOP (%) than control groups (n<sub>studies</sub>=16; n<sub>patients</sub>=650; WMD=14.25%; 95% CI [9.06; 19.45]; p<0.001; I<sup>2</sup>=98.7%). The greatest WMD in BOP reductions (%) were obtained by antiseptics (n<sub>s</sub>=5; n<sub>p</sub>=229; WMD=22.72%; 95% CI [19.40; 26.04]; p<0.001; I<sup>2</sup>=94.8%), followed by probiotics (n<sub>s</sub>=6; n<sub>p</sub>=260; WMD=12.11%; 95% CI [3.20; 21.03]; p=0.008; I<sup>2</sup>=93.3%)<i>,</i> and systemic antibiotics (n<sub>s</sub>=3; n<sub>p</sub>=101; WMD=5.97%; 95% CI [1.34; 10.59]; p=0.012; I<sup>2</sup>=58.1%). Disease resolution was scarcely reported (n=6).</p> <h2>Conclusions</h2> <p>Significant clinical improvements can be obtained when professional submarginal instrumentation is combined with patient-performed or administered (by prescription) adjunctive measures, although a complete disease resolution may not be achieved.</p> <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://onlinelibrary.wiley.com/doi/10.1111/jcpe.13791?af=R" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-16447194657216977912023-02-16T22:32:00.000-08:002023-02-16T22:34:17.687-08:00The Efficacy of Implant Surface Decontamination Using Chemicals during Surgical Treatment of Peri‐implantitis: A Systematic Review and Meta‐Analysis<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c348f0ce?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://onlinelibrary.wiley.com/doi/10.1111/jcpe.13794?af=R" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">The Efficacy of Implant Surface Decontamination Using Chemicals during Surgical Treatment of Peri‐implantitis: A Systematic Review and Meta‐Analysis</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2F%28ISSN%291600-051X">Journal of Clinical Periodontology</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> <h2>ABSTRACT</h2> <h2>Aim</h2> <p>To answer the following PICOS question: in adult patients with peri-implantitis, what is the efficacy of surgical therapy with chemical surface decontamination of implant surfaces in comparison with surgical therapy alone or surgery with placebo decontamination, on probing pocket depth (PD) reduction and bleeding on probing (BoP)/suppuration on probing (SoP), in randomized controlled clinical trials (RCTs) and non-RCTs with at least 6 months of follow-up?</p> <h2>Materials and Methods</h2> <p>Six databases were searched from their inception up to May 20, 2022. Data on clinical outcome variables were pooled and analyzed using mean differences (MDs), Risk Ratios (RR) or Risk Differences (RD) as appropriate, 95% confidence intervals (CI), and prediction intervals (PIs) in the case of significant heterogeneity. Primary outcomes were determined as changes in PD and BoP/SoP. Secondary outcomes were detrmined as radiographic marginal bone loss (MBL), implant loss, and disease resolution. PROSPERO registration number: CRD42022325603.</p> <h2>Results</h2> <p>Six RCTs - two moderate, three high, and one low risk of bias (RoB) studies - were included. These studies test the adjunctive effect of photodynamic therapy (PDT), chlorhexidine (CHX), and administration of local antibiotics (LAbs) during surgery on the clinical outcome. In a single 12-month study, the adjunctive use of local antibiotics showed a clinically relevant reduction of PD )MD= 1.44; 95% CI [0.40; -2.48] and MBL (MD= 1.21; 95% CI [0.44; 1.98]; one trial, 32 participant). PDT showed a small but significant reduction in BoP (MD= 7.41%; 95% CI [0.81; 14.00]; P=0.028; two trials; 42 participants). Treatment with CHX resulted in no significant changes in PD, BoP, or MBL compared to placebo saline solution. None of the interventions affected disease resolution and implant loss. Certainty of the evidence was very low for all outcome measures assessed.</p> <h2>Conclusions</h2> <p>Within the limitations of this systematic review and the meta-analysis, adjunctive use of chemicals such as PDT, CHX, LAbs for surface decontamination during surgery of peri-implantitis cannot be recommended as superior to standard debridement procedures (mechanical debridement +/- saline).</p> <p>This article is protected by copyright. All rights reserved.</p> <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://onlinelibrary.wiley.com/doi/10.1111/jcpe.13794?af=R" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-91242712623849422092023-02-16T22:31:00.001-08:002023-02-16T22:31:16.704-08:00Autophagy and its role in osteosarcoma<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c34392db?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://onlinelibrary.wiley.com/doi/10.1002/cam4.5407?af=R" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">Autophagy and its role in osteosarcoma</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2F%28ISSN%292045-7634">Cancer Medicine</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> <div class="pin_container" style="float:none"><div id="pc_636024" class="pin_chiclet pc_first" title="Pin this image to Pinterest. Right-click to turn-off this feature."><span class="icon-service_pinterest-16x16"></span></div><img src="https://www.inoreader.com/camo/sP_aBvSxMbIA2byqakpwxH0lU7He2hLeKdTlebeSaR4k,b64/aHR0cHM6Ly9vbmxpbmVsaWJyYXJ5LndpbGV5LmNvbS9jbXMvYXNzZXQvZjkxMTJhMjgtODIwZi00NDNhLTlmMzItYzM3Mzc5OTM4OWE2L2NhbTQ1NDA3LXRvYy0wMDAxLW0ucG5n" alt="Autophagy and its role in osteosarcoma" data-original-src="https://onlinelibrary.wiley.com/cms/asset/f9112a28-820f-443a-9f32-c373799389a6/cam45407-toc-0001-m.png" style="max-width: 650px; height: auto; object-fit: contain;" class="article_block_image"></div><br> <p>In this review, we summarized the role of autophagy in OS proliferation, metastasis, chemotherapy, radiotherapy, and immunotherapy. And we think that autophagy-related genes and pathways could serve as potential targets for OS therapy.</p> <br> <h2>Abstract</h2> <p>Osteosarcoma (OS) is the most common bone malignancy and preferably occurs in children and adolescents. Despite significant advances in surgery and chemotherapy for OS over the past few years, overall survival rates of OS have reached a bottleneck. Thus, extensive researches aimed at developing new therapeutic targets for OS are urgently needed. Autophagy, a conserved process which allows cells to recycle altered or unused organelles and cellular components, has been proven to play a critical role in multiple biological processes in OS. In this article, we summarized the association between autophagy and proliferation, metastasis, chemotherapy, radiotherapy, and immunotherapy of OS, revealing that autophagy-related genes and pathways could serve as potential targets for OS therapy.</p> <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://onlinelibrary.wiley.com/doi/10.1002/cam4.5407?af=R" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-72533852489567001292023-02-16T22:30:00.001-08:002023-02-16T22:30:04.438-08:00Onychomycosis associated with diabetic foot syndrome: a systematic review<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c344632c?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://onlinelibrary.wiley.com/doi/10.1111/myc.13577?af=R" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">Onychomycosis associated with diabetic foot syndrome: a systematic review</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2F%28ISSN%291439-0507">Mycoses</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> <h2>Abstract</h2> <h2>Background</h2> <p>A systematic review was conducted to investigate the prevalence of onychomycosis in patients with diabetes. The association of onychomycosis with risk factors in patients with diabetic foot syndrome was also examined.</p> <h2>Methods</h2> <p>The recommendations in the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist were applied, and the included studies were assessed using the Strengthening the Reporting of Observational studies in Epidemiology (STROBE) method. Searches were conducted in October 2022 using PubMed (Medline) and Scopus for clinical studies, clinical trials, comparative studies, observational studies, and randomised clinical trials or controlled clinical trials addressing the prevalence and consequences of onychomycosis in patients with diabetes, diagnoses, or treatments. Two authors performed the study selection and data extraction, and any discrepancies between the two reviewers were resolved through discussion with a third reviewer.</p> <h2>Results</h2> <p>The systematic review included nine studies that met the inclusion criteria, and these studies enrolled 5426 patients with diabetes. Among these patients, 28.55% had onychomycosis that was mainly caused by <i>Trichophyton rubrum</i>. A significant association was found between the occurrence of onychomycosis and the presence of diabetic neuropathy (p=0.012) and elevated glycosylated haemoglobin values (p=0.039). There was no significant association between onychomycosis and ulceration (p=0.185). Eight studies had a grade 4 level of evidence and a grade C recommendation, and one study had a grade 1b level of evidence and a grade A recommendation.</p> <h2>Conclusion</h2> <p>The information described in the literature is insufficient and heterogeneous regarding the association of risk factors and ulceration in patients with diabetic foot compared with developing onychomycosis. There is also a need to implement onychomycosis diagnostic testing instead of relying only on a clinical diagnosis. Additional prospective, randomised, comparative studies are needed to increase the quality of studies in the literature.</p> <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://onlinelibrary.wiley.com/doi/10.1111/myc.13577?af=R" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-16442237526827002012023-02-16T22:29:00.001-08:002023-02-16T22:29:17.088-08:00Risky business: Understanding the association between objective COVID‐19 occupational risk features and worker subjective risk perceptions<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c359a0ec?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://bpspsychub.onlinelibrary.wiley.com/doi/10.1111/joop.12431?af=R" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">Risky business: Understanding the association between objective COVID‐19 occupational risk features and worker subjective risk perceptions</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2F%28ISSN%292044-8325">Journal of Occupational and Organizational Psychology</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> <h2>Abstract</h2> <p>Many workers are at risk of contracting COVID-19 through work, and subjective perceptions of COVID-19 risk are important predictors of worker attitudes and behaviours. However, little to no research provides comprehensive examination of objective COVID-19 occupational risk factors and how, or under what conditions, these factors relate to subjective risk perceptions. Using two wave survey data matched with archival data from the Occupational Information Network (O*Net) and county-level COVID-19 case data (<i>N</i> = 295), we examine how objective COVID-19 occupational risk relates to workers' subjective risk of contracting COVID-19 at work. We also examine the moderating roles of financial frailty, adherence to governmental workplace safety recommendations, and local COVID-19 threat. Results indicate that objective COVID-19 occupational risk significantly predicts subjective risk of contracting COVID-19 at work. Moreover, factors representing in-person work conducted in close proximity to others accounted for a large proportion of explained variance in subjective risk. There was no support for moderation; however, financial frailty and workplace safety had independent main effects on subjective risk perceptions. Our results have theoretical implications for the Economic Stress and COVID-19 Occupational Risk model (Sinclair et al., <i>Appl</i>. <i>Psychol</i>., <i>70</i>, 2021, 85), individual models of subjective risk perceptions, and practical implications for mitigating occupational risk at work.</p> <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://bpspsychub.onlinelibrary.wiley.com/doi/10.1111/joop.12431?af=R" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-40300747417600245302023-02-16T22:16:00.001-08:002023-02-16T22:16:25.711-08:00PPAR-γ activation promotes xenogenic bioroot regeneration by attenuating the xenograft induced-oxidative stress<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c36cb2d6?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://www.nature.com/articles/s41368-023-00217-4" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">PPAR-γ activation promotes xenogenic bioroot regeneration by attenuating the xenograft induced-oxidative stress</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://www.nature.com/ijos/current_issue/">International Journal of Oral Science - Issue</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> <p class="p_no_top"><div class="pin_container" style="float:none"><div id="pc_252993" class="pin_chiclet pc_first" title="Pin this image to Pinterest. Right-click to turn-off this feature."><span class="icon-service_pinterest-16x16"></span></div><img src="https://www.inoreader.com/camo/szUyhcRpd1mDA-jvq7skHG_FQ7_bGKWEbJ6DFd-xZ8oE,b64/aHR0cHM6Ly9tZWRpYS5zcHJpbmdlcm5hdHVyZS5jb20vbTY4NS9zcHJpbmdlci1zdGF0aWMvaW1hZ2UvYXJ0JTNBMTAuMTAzOCUyRnM0MTM2OC0wMjMtMDAyMTctNC9NZWRpYU9iamVjdHMvNDEzNjhfMjAyM18yMTdfRmlnMV9IVE1MLnBuZw" alt="41368_2023_217_Fig1_HTML.png" data-original-src="https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41368-023-00217-4/MediaObjects/41368_2023_217_Fig1_HTML.png" style="max-width: 650px; height: auto; object-fit: contain; width: 100%;" class="article_block_image"></div><br></p> <p>International Journal of Oral Science, Published online: 16 February 2023; <a href="https://www.nature.com/articles/s41368-023-00217-4" target="_blank" rel="noopener" class="underlink bluelink">doi:10.1038/s41368-023-00217-4</a></p>PPAR-γ activation promotes xenogenic bioroot regeneration by attenuating the xenograft induced-oxidative stress <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://www.nature.com/articles/s41368-023-00217-4" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-19564800572714680922023-02-16T22:10:00.000-08:002023-02-16T22:12:42.397-08:00RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c36cb2de?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="https://www.nature.com/articles/s41368-023-00216-5" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://www.nature.com/ijos/current_issue/">International Journal of Oral Science - Issue</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> <p class="p_no_top"><div class="pin_container" style="float:none"><div id="pc_108535" class="pin_chiclet pc_first" title="Pin this image to Pinterest. Right-click to turn-off this feature."><span class="icon-service_pinterest-16x16"></span></div><img src="https://www.inoreader.com/camo/s1J5xhqBs1SgrcOzVqGvfadB4hWa7KIv4QC7Uj-qisBQ,b64/aHR0cHM6Ly9tZWRpYS5zcHJpbmdlcm5hdHVyZS5jb20vbTY4NS9zcHJpbmdlci1zdGF0aWMvaW1hZ2UvYXJ0JTNBMTAuMTAzOCUyRnM0MTM2OC0wMjMtMDAyMTYtNS9NZWRpYU9iamVjdHMvNDEzNjhfMjAyM18yMTZfRmlnMV9IVE1MLnBuZw" alt="41368_2023_216_Fig1_HTML.png" data-original-src="https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41368-023-00216-5/MediaObjects/41368_2023_216_Fig1_HTML.png" style="max-width: 650px; height: auto; object-fit: contain; width: 100%;" class="article_block_image"></div><br></p> <p>International Journal of Oral Science, Published online: 16 February 2023; <a href="https://www.nature.com/articles/s41368-023-00216-5" target="_blank" rel="noopener" class="underlink bluelink">doi:10.1038/s41368-023-00216-5</a></p>RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="https://www.nature.com/articles/s41368-023-00216-5" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-22771927358463710382023-02-16T22:08:00.004-08:002023-02-16T22:11:07.170-08:00In vivo PIWI slicing in mouse testes deviates from rules established in vitro [LETTER TO THE EDITOR]<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c37099f3?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="http://rnajournal.cshlp.org/cgi/content/short/29/3/308?rss=1" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">In vivo PIWI slicing in mouse testes deviates from rules established in vitro [LETTER TO THE EDITOR]</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://rnajournal.cshlp.org/">RNA current issue</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> <p class="p_no_top"><div class="pin_container" style="float:none"><div id="pc_104311" class="pin_chiclet pc_first" title="Pin this image to Pinterest. Right-click to turn-off this feature."><span class="icon-service_pinterest-16x16"></span></div><img title="USA Scientific" src="https://www.inoreader.com/camo/s3NCQB2scpoRyZxACdmqThK-DGkEX7Zbd1k7RGar4KVA,b64/aHR0cHM6Ly9ybmFqb3VybmFsLmNzaGxwLm9yZy9hZHN5c3RlbS9ncmFwaGljcy84MDIxMTQ4NDcyMjk0MDc4L2dlbmVzZGV2L0NvbGQlMjBTcHJpbmclMjBIYXJib3IlMjBUT0MlMjBQaXBldHRlJTIwMjAyMyUyMDIuanBnP2FkPTU3MTc0JmFkdmlldz10cnVl" alt="Cold%20Spring%20Harbor%20TOC%20Pipette%2" data-original-src="https://rnajournal.cshlp.org/adsystem/graphics/8021148472294078/genesdev/Cold%20Spring%20Harbor%20TOC%20Pipette%202023%202.jpg?ad=57174&adview=true" style="max-width: 650px; height: auto; object-fit: contain;" class="article_block_image"></div><br></p> <p>Argonautes are small RNA-binding proteins, with some having small RNA-guided endonuclease (slicer) activity that cleaves target nucleic acids. One cardinal rule that is structurally defined is the inability of slicers to cleave target RNAs when nucleotide mismatches exist between the paired small RNA and the target at the cleavage site. Animal-specific PIWI clade Argonautes associate with PIWI-interacting RNAs (piRNAs) to silence transposable elements in the gonads, and this is essential for fertility. We previously demonstrated that purified endogenous mouse MIWI fails to cleave mismatched targets in vitro. Surprisingly, here we find using knock-in mouse models that target sites with cleavage-site mismatches at the 10th and 11th piRNA nucleotides are precisely sliced in vivo. This is identical to the slicing outcome in knock-in mice where targets are base-paired perfectly with the piRNA. Additionally, we find that pachytene piRNA-guided slicing in both these situations failed to initiate phased piRNA production from the specific target mRNA we studied. Instead, the two slicer cleavage fragments were retained in PIWI proteins as pre-piRNA and 17–19 nt by-product fragments. Our results indicate that PIWI slicing rules established in vitro are not respected in vivo, and that all targets of PIWI slicing are not substrates for piRNA biogenesis.</p> <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="http://rnajournal.cshlp.org/cgi/content/short/29/3/308?rss=1" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0tag:blogger.com,1999:blog-8408070992685444883.post-90085860679534721862023-02-16T22:08:00.003-08:002023-02-16T22:08:33.400-08:00RNA:RNA interaction in ternary complexes resolved by chemical probing [ARTICLE]<table class="arial" cellpadding="0" cellspacing="0" style="width:100%;font-family:'Roboto', Arial, sans-serif"> <tr> <td align="center"> <table id="header_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td align="left" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <table border="0" cellpadding="0" cellspacing="0" role="presentation" style="border-collapse:collapse;border-spacing:0px;"> <tbody> <tr> <td style="width:112px;"> <a href="https://www.inoreader.com/" target="_blank"> <img height="auto" src="https://www.inoreader.com/newsletter/images/email-logo.png" style="border:0;display:block;outline:none;text-decoration:none;height:auto;width:100%;font-size:13px;" width="112" /> </a> </td> </tr> </tbody> </table> </td> </tr> <tr> <td align="center" style="font-size:0px;padding:10px 0px;word-break:break-word;"> <p style="border-top:solid 1px #efefef;font-size:1px;margin:0px auto;width:100%;"> </p> </td> </tr> </table> <table id="content_table" cellpadding="0" cellspacing="0" style="width:100%;"> <tr> <td > <table width="100%" class="inner-table"> <tr height="20"></tr> <tr> <td width="24px" align="left" style="vertical-align: top;padding-top: 3px !important;"> <img src="https://www.inoreader.com/camo/sFAhpo2LofcgTxwruKRB4UjK3bH0Vz7m9UTFGRVXVSwg,40x40,r20,b64/aHR0cHM6Ly93d3cuaW5vcmVhZGVyLmNvbS9jZG4vcHJvZmlsZV9zb2NpYWxfcGljdHVyZS8xMDA1NjE1MDYxL2dvb2dsZV80MC9hNGM0ZDEwZDNlNGYwNzJlNmM1ZWJjMWFlOWZkNTkwNGIyYzU1MjViZGI0YmFmZDlhMmVhNDA3YTQyYmNhZjg1OTI1NjI1YWZkYzc2MjAwMjQ4MWU2ZTZkMDZjNWJhYzczZTBkZWMyYmEyNmJhYmYzZTRhN2FiMjdjZWUyYzAwZThkMDBkOGU5NWFmNjlkNzUzYWUzNjM5MzNmZjcxMWY3NjkwZWEzYzAyZDc3ZjBkNmUwZDE0MzIx" style="width:20px;height:20px;vertical-align:middle;" width="20" height="20"> </td> <td> <span style="font-size:16px;margin:20px 0;padding-bottom:10px;font-weight:bold;"> AlexandrosSfakianakis </span> <span style="font-size:16px;letter-spacing:-0.02rem;margin:20px 0;padding-bottom:10px;"> shared this article with you from <a href="https://www.inoreader.com/article/3a9c6e75c37099ff?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:underline;">Inoreader</a> </span> </td> </tr> </table> </td> </tr> <tr height="20"></tr> <tr> <td> <table style="padding: 20px;border: 1px solid #efefef;border-radius: 5px;" width="100%" class="inner-table"> <tr> <td> <div dir="ltr"> <a href="http://rnajournal.cshlp.org/cgi/content/short/29/3/317?rss=1" style="font-size:24px;line-height:28px;text-decoration:none;font-weight:bold;color: #1a2433;">RNA:RNA interaction in ternary complexes resolved by chemical probing [ARTICLE]</a> </div> </td> </tr> <tr> <td> <div style="margin-top:8px;"> <span style="color: #828d9d;">via</span> <a style="font-weight: normal;color: #828d9d; text-decoration: none;" href="http://rnajournal.cshlp.org/">RNA current issue</a> </div> </td> </tr> <tr> <td> <div class="article-content" style="font-size:16px;margin-top:16px;line-height:28px;font-family:'Merriweather', Georgia, serif;" dir="ltr"> <p class="p_no_top"><div class="pin_container" style="float:none"><div id="pc_242674" class="pin_chiclet pc_first" title="Pin this image to Pinterest. Right-click to turn-off this feature."><span class="icon-service_pinterest-16x16"></span></div><img title="USA Scientific" src="https://www.inoreader.com/camo/sTK8KbjmlY6zV1B5TAYfVzKGU3FzGgLxN4Y5-3IWNMqI,b64/aHR0cHM6Ly9ybmFqb3VybmFsLmNzaGxwLm9yZy9hZHN5c3RlbS9ncmFwaGljcy84MDc0MjgzMjQzMTkyMTEzL2dlbmVzZGV2L0NvbGQlMjBTcHJpbmclMjBIYXJib3IlMjBUT0MlMjBQaXBldHRlJTIwMjAyMyUyMDIuanBnP2FkPTU3MTc0JmFkdmlldz10cnVl" alt="Cold%20Spring%20Harbor%20TOC%20Pipette%2" data-original-src="https://rnajournal.cshlp.org/adsystem/graphics/8074283243192113/genesdev/Cold%20Spring%20Harbor%20TOC%20Pipette%202023%202.jpg?ad=57174&adview=true" style="max-width: 650px; height: auto; object-fit: contain;" class="article_block_image"></div><br></p> <p>RNA regulation can be performed by a second targeting RNA molecule, such as in the microRNA regulation mechanism. Selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE) probes the structure of RNA molecules and can resolve RNA:protein interactions, but RNA:RNA interactions have not yet been addressed with this technique. Here, we apply SHAPE to investigate RNA-mediated binding processes in RNA:RNA and RNA:RNA-RBP complexes. We use RNA:RNA binding by SHAPE (RABS) to investigate <i>microRNA-34a</i> (<i>miR-34a</i>) binding its mRNA target, the <i>silent information regulator 1</i> (m<i>SIRT1</i>), both with and without the Argonaute protein, constituting the RNA-induced silencing complex (RISC). We show that the seed of the mRNA target must be bound to the microRNA loaded into RISC to enable further binding of the compensatory region by RISC, while the naked <i>miR-34a</i> is able to bind the compensatory region without seed interaction. The method presented here provi des complementary structural evidence for the commonly performed luciferase-assay-based evaluation of microRNA binding-site efficiency and specificity on the mRNA target site and could therefore be used in conjunction with it. The method can be applied to any nucleic acid-mediated RNA- or RBP-binding process, such as splicing, antisense RNA binding, or regulation by RISC, providing important insight into the targeted RNA structure.</p> <div style="clear:both;"> </div> </div> </td> </tr> </table> </td> </tr> <tr height="40"></tr> <tr> <td> <a href="http://rnajournal.cshlp.org/cgi/content/short/29/3/317?rss=1" target="_blank" style="text-decoration:none;padding:10px 24px;font-weight:500;background-color:#3d6baa;color:#ffffff;border-radius:3px;border:1px solid #3d6baa; text-align: center;font-size: 16px;">View on Web</a> </td> </tr> <tr height="20"></tr> </table> </td> </tr> </table> <table id="footer_table" cellpadding="0" cellspacing="0" style="100%"> <tr> <td style="font-size: 14px;text-align: left;"> <table width="100%" class="inner-table"> <tr> <td> <p style="border-top:1px solid #efefef;padding-top:24px;margin-top:24px;color: #828d9d;"> <a href="https://www.inoreader.com?utm_source=email_sharing&utm_campaign=u1005615061&utm_medium=email" style="text-decoration:none;color: #828d9d;">Inoreader</a>. Take back control of your news feed. Follow us on <a href="http://www.twitter.com/Inoreader" style="text-decoration:none;color: #828d9d;">Twitter</a> and <a href="http://www.facebook.com/Inoreader" style="text-decoration:none;color: #828d9d;">Facebook</a>. </p> </td> </tr> </table> </td> </tr> </table> </td> </tr> </table> Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,http://www.blogger.com/profile/12272646564356543767noreply@blogger.com0